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KMID : 0378119850120010162
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Chungnam Medical Journal
1985 Volume.12 No. 1 p.162 ~ p.169
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The Correlation of Intravenous Anesthetics, Muscle Relaxants and Local Anesthetics with Acetylcholine Contracture of Isolated Tracheal Preparation of Mongrel Dog in Vitro
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Abstract
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Severe tronchospasm occuring during general anesthesia is rare but potentially lethal anesthetic emergency, Several anesthetics charge with that situation. To assess correlation on airway smooth muscle, the authors studied the effects of three intravenous anesthetics, four muscle relaxants and three local anesthetics that used on acetylcholine 10ug/cc induced tone of mongrel dog tracheal chains.
The results are summarized as follow:
1. In the intravenous anesthetics group, thiopental and propanidid induced dose-dependent relaxation on acetylcholine contracture significantly, while ketamine induced variable contraction according to dose administered.
2. In the muscle relaxants group, pancuronium and gallamine induced dose-dependent relaxation on acetrlcholine contracture significantly, while succinylcholine and d-tubocurarine induced dose-dependent contracture significantly.
3. the local anesthetics group, lidocaine and procaine showed dose-dependent relaxation anacetylcholine contracture significantly, but tetracaine produced contraction at lower concentration and relaxation at higher concentration.
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